In July 2001, I had a significant failure to cure someone who had become seasick. The victim was a 19 year old male, weighing about 180 pounds. This individual got sick before he got aboard the boat. He had been riding in the back seat of a van on the drive from Portland, Oregon to Hammand boat basin near the mouth of the Columibia River. Walking down the rickety, swaying dock he got sick.
I told him if he wanted to go home, that he could catch a ride with the owner back to I-5 and his dad would come pick him up. He said he was "game" and would like to go anyway. He got good and sick by the time we crossed the bar and was sick for the next 20 hours, all the way to Quillieute River, Washington. Where we dropped him off.
I tried the usual treatment, which consisted of 25mg Meclizine chewable, chewed and dissolved but not swallowed. The Meclizine was totally ineffective. He indicated that Dramamine had worked on him before, so we went to Chewable Dramamine. We tried 50mg. At first it did not seem effective, but I kept pushing to get more in him and at 75mg, he seemed to have stabilized. And for a time said that he felt pretty good, but within 2 hours he started vomiting again and I was unable to get him to take any more medication of any kind. He stayed sick.

I had some Compazine suppositories(prescription), but he would have none of that. I think that it in a pinch, you could resort to rubbing the suppository on the soft skin of the forearm or perhaps behind the ear if the victim won't cooperate.

This case demonstrates 2 things to me. He stabilized when I got him to 75mg of Dramamine, but not before and he was resistant to my suggestions to do so. That patient cooperation is the critical element in successful cures.

There will be more on this after I debrief him.